As of macOS 10.13 High Sierra, Data Rescue no longer has access to startup drives in normal Mac desktop environments. Due to this update, scanning and recovering from the startup drive is restricted.
The System Integrity Protection (SIP) feature that Apple added to macOS 10.11 was updated to offer more robust security protections. These updates bar programs from reading the startup drive and security components such as your system files from being deleted or overwritten.
There is a way to work around Apple’s update. By creating a bootable recovery drive you can run Data Rescue in an environment that safely accesses your startup drive. To do this, you will need a drive (USB is preferred) that is 16GB or greater and to follow the steps shown below.
Begin the process by using Data Rescue's "Create Recovery Drive" feature.
Select a drive to be used as your recovery drive. It must be 8GB or greater.
The drive you selected for a recovery drive will have any existing data overwritten.
You have successfully made a recovery drive! Now you can scan this device with Data Rescue.